Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 13/20 | 0.78 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363141 | 1.00 | SERPINE1 (0.78) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7359303 | 0.88 | SERPINE1 (1.00) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7359291 | 0.88 | SERPINE1 (1.00) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7355877 | 0.84 | SERPINE1 (0.84) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7355888 | 0.84 | SERPINE1 (0.84) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7358033 | 0.78 | SERPINE1 (1.00) | SERPINE1 | |
| SCHEMBL7358028 | 0.78 | SERPINE1 (1.00) | SERPINE1 | |
| SCHEMBL7353995 | 0.77 | SERPINE1 (1.00) | SERPINE1 | |
| SCHEMBL7357832 | 0.77 | SERPINE1 (0.80) | SERPINE1 | |
| SCHEMBL7363192 | 0.77 | SERPINE1 (0.82) | SERPINE1CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995032190-A2 | PHARMACEUTICAL DIKETOPIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-11-30 | — | — | WO | claimed |
| US-5750530-A | PLASMINOGEN ACTIVATOR INHIBITORS | XENOVA LIMITED (GB) | 1998-05-12 | — | — | US | disclosed |
| WO-1995032190-A2 | PHARMACEUTICAL DIKETOPIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-11-30 | — | — | WO | disclosed |