Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.85 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.85 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.85 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.85 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.61 |
| ▸ | CFTR | P13569 | 3/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361489 | 0.93 | PDE4D (0.74) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| Pyridopyridazinone SCHEMBL31427010 | 0.92 | PDE4A (1.00) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| Pyridopyridazinone SCHEMBL31427009 | 0.92 | PDE4A (1.00) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| Pyridopyridazinone SCHEMBL6637552 | 0.92 | PDE4A (1.00) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| Pyridopyridazinone SCHEMBL7367220 | 0.91 | PDE4A (0.98) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7366898 | 0.89 | PDE4A (0.69) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7361180 | 0.85 | PDE4A (0.63) | PDE4APDE4DPDE4CPDE4BCFTR | |
| SCHEMBL7363642 | 0.85 | PDE4A (0.87) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL8306609 | 0.84 | PDE4A (0.84) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7365928 | 0.83 | PDE4A (0.66) | PDE4APDE4DPDE4CPDE4BPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-B1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX INC (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |