Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364245 | 1.00 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7364454 | 1.00 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7359066 | 0.94 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7359058 | 0.94 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7369011 | 0.94 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7367852 | 0.89 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7360680 | 0.87 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27529144 | 0.87 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7365291 | 0.86 | PDE4B (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3543217 | 0.84 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993007141-A1 | HETEROCYCLIC 3-PHENYLPYRROLIDIN-2-ONES, THEIR PREPARATION AND USE FOR THE MANUFACTURE OF A MEDICAMENT FOR INHIBITING TUMOR NECROSIS FACTOR PRODUCTION | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-15 | — | — | WO | claimed |
| WO-1993007141-A1 | HETEROCYCLIC 3-PHENYLPYRROLIDIN-2-ONES, THEIR PREPARATION AND USE FOR THE MANUFACTURE OF A MEDICAMENT FOR INHIBITING TUMOR NECROSIS FACTOR PRODUCTION | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-15 | — | — | WO | disclosed |