Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.68 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.68 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.68 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.68 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.68 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.68 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.47 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.47 |
| ▸ | PIM1 | P11309 | 4/20 | 0.45 |
| ▸ | GSK3A | P49840 | 3/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3162671 | 0.94 | KDM4E (0.59) | KDM4EGABRA1GABRG2GABRB3MAPK1 | |
| SCHEMBL11983338 | 0.92 | KDM4E (0.75) | KDM4EGABRA1GABRG2GABRB3MAPK1 | |
| SCHEMBL7368457 | 0.92 | KDM4E (0.57) | KDM4EGABRA1GABRG2GABRB3MAPK1 | |
| SCHEMBL3155522 | 0.89 | KDM4E (0.56) | KDM4EGABRA1GABRG2GABRB3MAPK1 | |
| SCHEMBL3160464 | 0.89 | KDM4E (0.54) | KDM4EGABRA1GABRG2GABRB3MAPK1 | |
| SCHEMBL5818550 | 0.88 | KDM4E (0.56) | KDM4EGABRA1GABRG2GABRB3MAPK1 | |
| SCHEMBL10946059 | 0.87 | MAP2K1 (0.52) | KDM4EGABRA1GABRG2GABRB3MAPK1 | |
| SCHEMBL10736316 | 0.87 | KDM4E (0.51) | KDM4EGABRA1GABRG2GABRB3MAPK1 | |
| SCHEMBL7364783 | 0.86 | TLR8 (0.50) | KDM4EGABRA1GABRG2GABRB3MAPK1 | |
| SCHEMBL1873521 | 0.85 | KDM4E (0.49) | KDM4EGABRA1GABRG2GABRB3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4521422-A | ANTICONVULSANT, ANTIEPILEPTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS | AMERICAN CYANAMID COMPANY (US) | 1985-06-04 | — | — | US | disclosed |
| EP-0129847-A2 | Aryl and heteroaryl[7-(aryl and heteroaryl)-pyrazolo-[1,5-a]-pyrimidin-3-yl]methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | disclosed |