Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.84 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.84 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092611 | 1.00 | CYP1A2 (0.84) | CYP1A2MAPK1SMN1; SMN2HRH3ALDH1A1 | |
| SCHEMBL26495548 | 1.00 | CYP1A2 (0.84) | CYP1A2MAPK1SMN1; SMN2HRH3ALDH1A1 | |
| SCHEMBL10448990 | 1.00 | CYP1A2 (0.84) | CYP1A2MAPK1SMN1; SMN2HRH3ALDH1A1 | |
| SCHEMBL26495605 | 1.00 | CYP1A2 (0.84) | CYP1A2MAPK1SMN1; SMN2HRH3ALDH1A1 | |
| SCHEMBL27033239 | 1.00 | CYP1A2 (0.84) | CYP1A2MAPK1SMN1; SMN2HRH3ALDH1A1 | |
| SCHEMBL547192 | 0.98 | CYP1A2 (0.88) | CYP1A2MAPK1SMN1; SMN2HRH3ALDH1A1 | |
| SCHEMBL9152244 | 0.98 | CYP1A2 (0.80) | CYP1A2MAPK1SMN1; SMN2HRH3ALDH1A1 | |
| SCHEMBL2639576 | 0.98 | CYP1A2 (0.88) | CYP1A2MAPK1SMN1; SMN2HRH3ALDH1A1 | |
| SCHEMBL9151071 | 0.98 | CYP1A2 (0.80) | CYP1A2MAPK1SMN1; SMN2HRH3ALDH1A1 | |
| SCHEMBL9154341 | 0.98 | CYP1A2 (0.80) | CYP1A2MAPK1SMN1; SMN2HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891362-A1 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LIMITED (GB) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036903-A1 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LIMITED (GB) | 1997-10-09 | — | — | WO | disclosed |