Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366942 | 1.00 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7367621 | 1.00 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7360083 | 0.90 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7362317 | 0.90 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7360077 | 0.90 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7363289 | 0.89 | PDE4B (0.60) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL30530004 | 0.89 | PDE4B (0.60) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7365302 | 0.83 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7361120 | 0.83 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2988958 | 0.83 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037367-A | Substituted-pent-4-ynoic acids | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-14 | — | — | US | claimed |
| EP-0827495-A4 | SUBSTITUTED-PENT-4-YNOIC ACIDS | SMITHKLINE BEECHAM CORP (US) | 1998-11-04 | — | — | EP | claimed |
| EP-0827495-A1 | SUBSTITUTED-PENT-4-YNOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-11 | — | — | EP | claimed |
| WO-1997003945-A1 | SUBSTITUTED-PENT-4-YNOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-06 | — | — | WO | claimed |
| US-6037367-A | Substituted-pent-4-ynoic acids | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-14 | — | — | US | disclosed |
| EP-0827495-A4 | SUBSTITUTED-PENT-4-YNOIC ACIDS | SMITHKLINE BEECHAM CORP (US) | 1998-11-04 | — | — | EP | disclosed |
| EP-0827495-A1 | SUBSTITUTED-PENT-4-YNOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-11 | — | — | EP | disclosed |
| WO-1997003945-A1 | SUBSTITUTED-PENT-4-YNOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-06 | — | — | WO | disclosed |