Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366477 | 0.92 | PDE4A (0.46) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7357772 | 0.90 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4CEPHX2 | |
| SCHEMBL7357871 | 0.88 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4CEPHX2 | |
| SCHEMBL7358879 | 0.88 | PDE4A (0.50) | PDE4APDE4DPDE4BPDE4CEPHX2 | |
| SCHEMBL7363382 | 0.88 | PDE4A (0.50) | PDE4APDE4DPDE4BPDE4CEPHX2 | |
| SCHEMBL7358728 | 0.87 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7361991 | 0.87 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7359443 | 0.86 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7358660 | 0.84 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7361030 | 0.84 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0827495-A4 | SUBSTITUTED-PENT-4-YNOIC ACIDS | SMITHKLINE BEECHAM CORP (US) | 1998-11-04 | — | — | EP | disclosed |
| EP-0827495-A1 | SUBSTITUTED-PENT-4-YNOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-11 | — | — | EP | disclosed |
| WO-1997003945-A1 | SUBSTITUTED-PENT-4-YNOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-06 | — | — | WO | disclosed |