Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 10/20 | 1.00 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.55 |
| ▸ | PLAU | P00749 | 5/20 | 0.48 |
| ▸ | PLG | P00747 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365097 | 0.90 | F2 (1.00) | F2PRSS1PLAUPLGF10 | |
| SCHEMBL7360119 | 0.85 | F2 (0.75) | F2PLAUPLG | |
| SCHEMBL7363988 | 0.85 | F2 (1.00) | F2PRSS1PLAUPLGMAPT | |
| SCHEMBL7362115 | 0.81 | F2 (0.82) | F2PRSS1PLAUPLGF10 | |
| SCHEMBL7364712 | 0.78 | F2 (0.64) | F2PRSS1PLAUTP53F10 | |
| SCHEMBL7366569 | 0.78 | F2 (0.74) | F2PRSS1PLAUPLGF10 | |
| SCHEMBL27943803 | 0.73 | F2 (0.56) | F2 | |
| SCHEMBL7367913 | 0.73 | F2 (1.00) | F2PRSS1F10 | |
| SCHEMBL7362114 | 0.73 | F2 (0.69) | F2PRSS1F10 | |
| SCHEMBL7359608 | 0.72 | F2 (0.68) | F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960102-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | Du Pont Pharmaceuticals Company (US) | 1999-12-01 | — | — | EP | claimed |
| WO-1998001428-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-01-15 | — | — | WO | claimed |
| US-6043257-A | ANTICOAGULANT; PYRIDINE SUBSTITUTED INDAZOLE COMPOUND | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-03-28 | — | — | US | disclosed |
| US-5886191-A | ANTICOAGULANTS | DUPONT PHARMACEUTICALS COMPANY (US) | 1999-03-23 | — | — | US | disclosed |