Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.37 |
| ▸ | ITGAL | P20701 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17593127 | 0.82 | ELANE (0.50) | ELANEGAAITGB2ICAM1ITGAL | |
| SCHEMBL28538161 | 0.76 | ELANE (0.55) | ELANEGAAITGB2ICAM1ITGAL | |
| SCHEMBL3284001 | 0.76 | ELANE (0.55) | ELANEGAAITGB2ICAM1ITGAL | |
| SCHEMBL16174913 | 0.73 | ELANE (0.51) | ELANEGAAITGB2ICAM1ITGAL | |
| SCHEMBL7353378 | 0.72 | ELANE (0.40) | ELANEGAABACE1MAOAMAOB | |
| SCHEMBL11696413 | 0.71 | CNR2 (0.43) | ELANEGAABACE1MAOAMAOB | |
| SCHEMBL16174684 | 0.70 | ELANE (0.45) | ELANEMAOAMAOBNPSR1L3MBTL1 | |
| SCHEMBL29256181 | 0.70 | ELANE (0.56) | ELANEGAAITGB2ICAM1ITGAL | |
| SCHEMBL16174938 | 0.69 | ELANE (0.47) | ELANEITGB2ICAM1ITGALNPSR1 | |
| SCHEMBL16174950 | 0.69 | ELANE (0.47) | ELANEITGB2ICAM1ITGALNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6060600-A | TREATMENT OF AIDS AND OTHER DISEASES CAUSED BY RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 2000-05-09 | — | — | US | disclosed |
| US-5977169-A | FOR TREATMENT OF A PERSON WITH AIDS OR AIDS RELATED DISEASES | PHARMACIA & UPJOHN COMPANY | 1999-11-02 | — | — | US | disclosed |
| EP-0817786-A1 | SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 1998-01-14 | — | — | EP | disclosed |
| WO-1996029333-A1 | SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 1996-09-26 | — | — | WO | disclosed |
| EP-0720607-A1 | SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995007901-A1 | SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1995-03-23 | — | — | WO | disclosed |