Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.82 |
| ▸ | PDE4A | P27815 | 14/20 | 0.82 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.82 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.82 |
| ▸ | VEGFA | P15692 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3547968 | 0.91 | PDE4A (0.84) | PDE4BPDE4APDE4CPDE4DVEGFA | |
| SCHEMBL3547495 | 0.91 | PDE4A (0.84) | PDE4BPDE4APDE4CPDE4DVEGFA | |
| SCHEMBL5222151 | 0.91 | PDE4A (0.84) | PDE4BPDE4APDE4CPDE4DVEGFA | |
| SCHEMBL7448224 | 0.91 | PDE4A (0.83) | PDE4BPDE4APDE4CPDE4DVEGFA | |
| SCHEMBL7361518 | 0.90 | PDE4A (1.00) | PDE4BPDE4APDE4CPDE4DVEGFA | |
| SCHEMBL931963 | 0.90 | PDE4A (1.00) | PDE4BPDE4APDE4CPDE4DVEGFA | |
| SCHEMBL7358081 | 0.90 | PDE4A (1.00) | PDE4BPDE4APDE4CPDE4DVEGFA | |
| SCHEMBL7362901 | 0.90 | PDE4A (1.00) | PDE4BPDE4APDE4CPDE4DVEGFA | |
| SCHEMBL3541352 | 0.90 | PDE4A (0.82) | PDE4BPDE4APDE4CPDE4DVEGFA | |
| SCHEMBL5789908 | 0.90 | PDE4A (0.82) | PDE4BPDE4APDE4CPDE4DVEGFA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0584208-A4 | — | — | 1994-03-23 | — | — | EP | disclosed |
| EP-0584208-A1 | PYRROLIDINONES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-03-02 | — | — | EP | disclosed |
| WO-1992019594-A1 | PYRROLIDINONES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-11-12 | — | — | WO | disclosed |