Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5396757 | 0.87 | POLA1 (0.52) | POLA1KDM1ASIGMAR1NPC1POLB | |
| SCHEMBL7967461 | 0.87 | POLA1 (0.52) | POLA1KDM1ASIGMAR1NPC1POLB | |
| SCHEMBL7967459 | 0.83 | POLA1 (0.45) | POLA1KDM1ASIGMAR1NPC1POLB | |
| SCHEMBL29587519 | 0.77 | POLA1 (0.51) | POLA1KDM1ASIGMAR1CYP2C19CYP2C9 | |
| SCHEMBL4984411 | 0.77 | POLA1 (0.51) | POLA1KDM1ASIGMAR1CYP2C19CYP2C9 | |
| SCHEMBL7172371 | 0.77 | SMN1; SMN2 (0.56) | POLA1KDM1ASIGMAR1SMN1; SMN2NPC1 | |
| SCHEMBL6580889 | 0.75 | POLA1 (0.55) | POLA1KDM1ASIGMAR1SMN1; SMN2NPC1 | |
| SCHEMBL9252967 | 0.75 | KDM1A (0.50) | POLA1KDM1ASIGMAR1CYP2C19CYP2C9 | |
| SCHEMBL1846867 | 0.74 | POLA1 (0.51) | POLA1KDM1ASIGMAR1NPC1POLB | |
| SCHEMBL12930797 | 0.74 | POLA1 (0.43) | POLA1KDM1ASIGMAR1CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265397-B1 | Amidino derivatives and their use as thrombin inhibitors | ASTRAZENECA AB (SE) | 2001-07-24 | — | — | US | disclosed |
| EP-1012140-A1 | NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS | AstraZeneca AB (SE) | 2000-06-28 | — | — | EP | disclosed |
| WO-1998057932-A1 | NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS | ASTRA AKTIEBOLAG (SE) | 1998-12-23 | — | — | WO | disclosed |