Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | COMT | P21964 | 1/20 | 0.46 |
| ▸ | PDE9A | O76083 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.43 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.43 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.43 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369415 | 0.90 | ATM (0.49) | MAPK1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3652876 | 0.86 | NPSR1 (0.64) | ALDH1A1MEN1KMT2ASMN1; SMN2ATM | |
| SCHEMBL2886126 | 0.84 | GSK3A (0.52) | MAPK1ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL7362195 | 0.81 | MAP2K4 (0.57) | MAPK1ALDH1A1ATMNPSR1HPGD | |
| SCHEMBL7362532 | 0.80 | MAP2K4 (0.53) | MAPK1ATMNPSR1MAP2K4MAPKAPK3 | |
| SCHEMBL7368649 | 0.80 | MAPK1 (0.70) | MAPK1ALDH1A1SMN1; SMN2HPGDMAP2K4 | |
| SCHEMBL1786578 | 0.79 | ATM (0.73) | MAPK1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL19153217 | 0.79 | PARP1 (0.49) | CYP1A2L3MBTL1PARP1TSHRNPC1 | |
| SCHEMBL16535289 | 0.78 | LRRK2 (0.61) | ALDH1A1SMN1; SMN2ATMNPSR1HPGD | |
| SCHEMBL17887975 | 0.76 | ITK (0.59) | MAPK1ALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |