SCHEMBL7366155

SCHEMBL7366155

O=C(NCc1cccc2ccccc12)c1cc([N+](=O)[O-])ccc1NC1CCCC1

nearest known ligand 0.60

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.60
KMT2A Q03164 2/20 0.55
TDP1 Q9NUW8 1/20 0.50
MEN1 O00255 1/20 0.49
SMN1; SMN2 Q16637 2/20 0.47
ALDH1A1 P00352 1/20 0.47
LMNA P02545 1/20 0.47
CRHBP P24387 1/20 0.47
CRHR2 Q13324 1/20 0.47
RORC P51449 1/20 0.45
CHRNB2 P17787 1/20 0.44
CHRNA4 P43681 1/20 0.44
THRB P10828 1/20 0.44
TBXA2R P21731 3/20 0.43
SLC6A2 P23975 1/20 0.43
SLC6A4 P31645 1/20 0.43
DRD3 P35462 1/20 0.43
NPSR1 Q6W5P4 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6938997 0.93 MAPT (0.51) MAPTKMT2ATDP1MEN1LMNA
SCHEMBL6938994 0.93 MAPT (0.51) MAPTKMT2ATDP1MEN1LMNA
SCHEMBL6939578 0.86 KMT2A (0.68) MAPTKMT2AMEN1SMN1; SMN2ALDH1A1
SCHEMBL6937248 0.85 MAPT (0.72) MAPTKMT2AMEN1SMN1; SMN2ALDH1A1
SCHEMBL6941716 0.85 MAPT (0.72) MAPTKMT2AMEN1SMN1; SMN2ALDH1A1
SCHEMBL6939812 0.84 MAPT (0.67) MAPTKMT2AMEN1SMN1; SMN2ALDH1A1
SCHEMBL6939682 0.84 MAPT (0.63) MAPTKMT2ASMN1; SMN2ALDH1A1LMNA
SCHEMBL6939378 0.82 MAPT (0.58) MAPTKMT2AMEN1SMN1; SMN2ALDH1A1
SCHEMBL6941778 0.81 MAPT (0.63) MAPTKMT2AMEN1SMN1; SMN2ALDH1A1
SCHEMBL6939456 0.80 MAPT (0.59) MAPTKMT2AMEN1SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001030745-A1 ANTHRANILIC ACID DERIVATIVES AS INHIBITORS OF THE CGMP-PHOSPHODIESTERASE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-05-03 WO disclosed