Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 8/20 | 0.66 |
| ▸ | DRD3 | P35462 | 6/20 | 0.66 |
| ▸ | DRD2 | P14416 | 6/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.63 |
| ▸ | HTR2C | P28335 | 2/20 | 0.63 |
| ▸ | HTR2B | P41595 | 2/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
| ▸ | ACHE | P22303 | 2/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | HTR2A | P28223 | 1/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.63 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.63 |
| ▸ | HTR3A | P46098 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368169 | 0.95 | DRD4 (0.64) | DRD4DRD3DRD2CYP3A4CYP1A2 | |
| SCHEMBL7371801 | 0.92 | DRD3 (0.72) | DRD4DRD3DRD2CYP3A4CYP1A2 | |
| SCHEMBL1502026 | 0.91 | DRD4 (0.73) | DRD4DRD3DRD2CYP3A4CYP1A2 | |
| SCHEMBL7375024 | 0.90 | DRD3 (0.58) | DRD4DRD3DRD2CYP3A4CYP1A2 | |
| SCHEMBL6682529 | 0.84 | DRD3 (0.85) | DRD4DRD3DRD2CYP3A4CYP1A2 | |
| SCHEMBL3361901 | 0.83 | DRD3 (0.85) | DRD4DRD3DRD2CYP3A4CYP1A2 | |
| SCHEMBL19236412 | 0.83 | DRD3 (0.85) | DRD4DRD3DRD2CYP3A4CYP1A2 | |
| SCHEMBL7373070 | 0.82 | DRD3 (0.74) | DRD4DRD3DRD2CYP3A4CYP1A2 | |
| SCHEMBL7371220 | 0.81 | DRD3 (0.69) | DRD4DRD3DRD2CYP3A4CYP1A2 | |
| SCHEMBL7366214 | 0.80 | DRD3 (0.70) | DRD4DRD3DRD2CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243959-B1 | SUBSTITUTED BENZAMIDE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1992-08-19 | — | — | EP | disclosed |
| US-4870074-A | Substituted benzamide derivatives, for enhancing gastrointestinal motility | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1989-09-26 | — | — | US | disclosed |
| EP-0243959-A1 | Substituted benzamide derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same | Dainippon Pharmaceutical Co., Ltd. (JP) | 1987-11-04 | — | — | EP | disclosed |