Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.61 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | PDE6D | O43924 | 1/20 | 0.47 |
| ▸ | PDE6A | P16499 | 1/20 | 0.47 |
| ▸ | PDE6G | P18545 | 1/20 | 0.47 |
| ▸ | PDE6B | P35913 | 1/20 | 0.47 |
| ▸ | PDE6C | P51160 | 1/20 | 0.47 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423055 | 1.00 | PDE5A (0.61) | PDE5AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7423061 | 1.00 | PDE5A (0.61) | PDE5AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14104620 | 0.77 | PDE5A (0.46) | PDE5AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7685541 | 0.74 | MEN1 (0.51) | PDE5AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7685549 | 0.74 | MEN1 (0.51) | PDE5AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1326138 | 0.73 | PDE5A (0.85) | PDE5A | |
| SCHEMBL1326142 | 0.73 | PDE5A (0.85) | PDE5A | |
| SCHEMBL1326139 | 0.73 | PDE5A (0.85) | PDE5A | |
| SCHEMBL14104621 | 0.70 | KMT2A (0.44) | PDE5AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7359519 | 0.69 | PDE5A (0.60) | PDE5APDE11APDE6DPDE6APDE6G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0740668-A1 | TETRACYCLIC DERIVATIVES, PROCESS OF PREPARATION AND USE | LABORATORIES GLAXO WELLCOME S.A. (FR) | 1996-11-06 | — | — | EP | claimed |
| WO-1995019978-A1 | TETRACYCLIC DERIVATIVES, PROCESS OF PREPARATION AND USE | LABORATOIRES GLAXO WELLCOME S.A. (FR) | 1995-07-27 | — | — | WO | claimed |
| EP-0839040-A1 | USE OF CGMP-PHOSPHODIESTERASE INHIBITORS TO TREAT IMPOTENCE | ICOS CORPORATION (US) | 1998-05-06 | — | — | EP | disclosed |
| WO-1997003675-A1 | USE OF CGMP-PHOSPHODIESTERASE INHIBITORS TO TREAT IMPOTENCE | ICOS CORPORATION (US) | 1997-02-06 | — | — | WO | disclosed |