Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 7/20 | 0.42 |
| ▸ | AKT2 | P31751 | 6/20 | 0.42 |
| ▸ | AKT3 | Q9Y243 | 6/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6801778 | 0.85 | EGFR (0.45) | TGFBR1AKT1AKT2AKT3CYP2C9 | |
| SCHEMBL7366554 | 0.83 | EGFR (0.41) | TGFBR1AKT1AKT2AKT3CYP2C9 | |
| SCHEMBL6797247 | 0.82 | EGFR (0.53) | AKT1AKT2AKT3CYP2C9TP53 | |
| SCHEMBL6797690 | 0.82 | EGFR (0.46) | AKT1AKT2AKT3TP53CYP17A1 | |
| SCHEMBL6798795 | 0.80 | EGFR (0.49) | AKT1AKT2AKT3CYP2C9TP53 | |
| SCHEMBL6800418 | 0.80 | AKT1 (0.43) | AKT1AKT2AKT3TP53NPC1 | |
| Hydrochloric Acid SCHEMBL6796872 | 0.78 | EGFR (0.43) | AKT1AKT2AKT3CYP2C9TP53 | |
| SCHEMBL6799820 | 0.78 | TP53 (0.47) | AKT1TP53RXFP1MCHR1MEN1 | |
| SCHEMBL6801892 | 0.78 | EGFR (0.44) | AKT1TP53NPC1SMN1; SMN2EGFR | |
| SCHEMBL6804831 | 0.77 | NPC1 (0.44) | TP53NPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874845-A1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024355-A1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-10 | — | — | WO | disclosed |