Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.81 |
| ▸ | MEN1 | O00255 | 3/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.81 |
| ▸ | MAPT | P10636 | 3/20 | 0.81 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.81 |
| ▸ | LMNA | P02545 | 1/20 | 0.81 |
| ▸ | POLB | P06746 | 1/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.81 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.81 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.81 |
| ▸ | TSHR | P16473 | 1/20 | 0.81 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.81 |
| ▸ | THPO | P40225 | 1/20 | 0.81 |
| ▸ | CACNA1F | O60840 | 7/20 | 0.76 |
| ▸ | CACNA1D | Q01668 | 7/20 | 0.76 |
| ▸ | CACNA1S | Q13698 | 7/20 | 0.76 |
| ▸ | CACNA1C | Q13936 | 7/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10823898 | 0.96 | CACNA1F (0.82) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL9476417 | 0.92 | MEN1 (0.84) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL7300924 | 0.91 | HIF1A (0.82) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL7161991 | 0.91 | HIF1A (0.86) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL7431297 | 0.91 | HIF1A (0.82) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL7281098 | 0.90 | HIF1A (0.81) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL3435101 | 0.90 | HIF1A (0.81) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| Nitrendipine SCHEMBL15516493 | 0.89 | HIF1A (1.00) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| (R)-Nitrendipine SCHEMBL38973 | 0.89 | HIF1A (1.00) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| (S)-Nitrendipine SCHEMBL120983 | 0.89 | HIF1A (1.00) | HIF1AMEN1KMT2AMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5137889-A | Hypotensive agents; coronary vasodilators; calcium antagonists; antiinflammatory agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-08-11 | — | — | US | disclosed |
| US-5034395-A | Hypotensive agents, carboxylated dihydropyridines | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-23 | — | — | US | disclosed |
| EP-0145434-A2 | Novel dihydropyridine derivatives and process for preparing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-19 | — | — | EP | disclosed |