Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DDRD2HTR2AHTR2C
The experimentally established mechanism targets of Sertindole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.84 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.84 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.84 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.84 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.84 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.84 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.84 |
| ▸ | HRH1 | P35367 | 2/20 | 0.84 |
| ▸ | MLNR | O43193 | 1/20 | 0.84 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.84 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.84 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.84 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.84 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.84 |
| ▸ | HTR1A | P08908 | 1/20 | 0.84 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.84 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.84 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.84 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.84 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sertindole SCHEMBL7363167 | 0.94 | KCNH2 (0.79) | KCNH2DRD2HTR2CHRH1MLNR | |
| Sertindole SCHEMBL112092 | 0.91 | KCNH2 (1.00) | KCNH2DRD2HTR2CHRH1MLNR | |
| Sertindole SCHEMBL29360085 | 0.91 | KCNH2 (1.00) | KCNH2DRD2HTR2CHRH1MLNR | |
| Sertindole SCHEMBL7363162 | 0.90 | KCNH2 (0.85) | KCNH2DRD2HTR2CHRH1MLNR | |
| Sertindole SCHEMBL28600134 | 0.90 | KCNH2 (0.98) | KCNH2DRD2HTR2CHRH1MLNR | |
| SCHEMBL8636687 | 0.86 | KCNH2 (0.90) | KCNH2DRD2HTR2CHRH1MLNR | |
| SCHEMBL8638643 | 0.86 | KCNH2 (0.90) | KCNH2DRD2HTR2CHRH1MLNR | |
| SCHEMBL7382323 | 0.85 | KCNH2 (0.88) | KCNH2DRD2HTR2CHRH1MLNR | |
| SCHEMBL7435229 | 0.85 | KCNH2 (0.88) | KCNH2DRD2HTR2CHRH1MLNR | |
| SCHEMBL8160638 | 0.85 | KCNH2 (0.76) | KCNH2DRD2HTR2CHRH1MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726898-B1 | PHENYLINDOLE COMPOUNDS | LUNDBECK & CO AS H (DK) | 2000-12-20 | — | — | EP | claimed |
| EP-0726898-B1 | PHENYLINDOLE COMPOUNDS | LUNDBECK & CO AS H (DK) | 2000-12-20 | — | — | EP | disclosed |
| EP-0726898-A1 | PHENYLINDOLE COMPOUNDS | H. LUNDBECK A/S (DK) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012591-A1 | PHENYLINDOLE COMPOUNDS | H. LUNDBECK A/S (DK) | 1995-05-11 | — | — | WO | disclosed |