Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369360 | 0.89 | MAPK8 (0.57) | KMT2AHPGDMAPK8LMNASMN1; SMN2 | |
| SCHEMBL7368824 | 0.86 | MAPK8 (0.64) | KMT2AHPGDMAPK8LMNASMN1; SMN2 | |
| SCHEMBL7370567 | 0.86 | MAPK8 (0.56) | KMT2AHPGDMAPK8LMNASMN1; SMN2 | |
| SCHEMBL7366732 | 0.83 | HPGD (0.61) | KMT2AHPGDMAPK8LMNASMN1; SMN2 | |
| SCHEMBL7371159 | 0.83 | MAPK8 (0.62) | KMT2AHPGDMAPK8LMNASMN1; SMN2 | |
| SCHEMBL7364427 | 0.82 | MAPK8 (0.52) | KMT2AHPGDMAPK8LMNACA2 | |
| SCHEMBL5394111 | 0.81 | MAPK8 (0.60) | KMT2AHPGDMAPK8LMNASMN1; SMN2 | |
| SCHEMBL5453356 | 0.81 | MAPK8 (0.60) | KMT2AHPGDMAPK8LMNASMN1; SMN2 | |
| SCHEMBL8756555 | 0.81 | MAPK8 (0.78) | KMT2AHPGDMAPK8ALDH1A1KDM4E | |
| SCHEMBL14193488 | 0.80 | MAPK8 (0.82) | KMT2AHPGDMAPK8LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |