Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 16/20 | 0.64 |
| ▸ | CNR1 | P21554 | 4/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740432 | 0.89 | CNR2 (0.66) | CNR2CNR1 | |
| SCHEMBL740431 | 0.89 | CNR2 (0.66) | CNR2CNR1 | |
| SCHEMBL738253 | 0.83 | CNR2 (0.80) | CNR2CNR1 | |
| SCHEMBL4116987 | 0.82 | CNR2 (0.68) | CNR2CNR1 | |
| SCHEMBL4117000 | 0.82 | CNR2 (0.68) | CNR2CNR1 | |
| SCHEMBL736401 | 0.81 | CNR2 (0.81) | CNR2CNR1 | |
| SCHEMBL736400 | 0.81 | CNR2 (0.81) | CNR2CNR1 | |
| SCHEMBL737775 | 0.80 | CNR2 (0.74) | CNR2CNR1 | |
| SCHEMBL737657 | 0.80 | CNR2 (0.74) | CNR2CNR1 | |
| SCHEMBL737762 | 0.79 | CNR2 (0.67) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138177-B2 | Benzimidazolone derivatives as CB2 receptor ligands | PFIZER INC. (US) | 2012-03-20 | — | — | US | claimed |
| EP-1861377-B1 | BENZIMIDAZOLONE DERIVATIVES AS CB2 RECEPTOR LIGANDS | PFIZER (US) | 2010-12-29 | — | — | EP | disclosed |