Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.57 |
| ▸ | HTT | P42858 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367460 | 1.00 | MAPT (0.57) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL7366780 | 0.86 | MAPT (0.55) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL7366776 | 0.86 | MAPT (0.55) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL524804 | 0.84 | MAPT (0.61) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL9533849 | 0.84 | RECQL (0.63) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL524803 | 0.84 | MAPT (0.61) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL5821775 | 0.82 | MAPT (0.59) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL6070983 | 0.82 | MAPT (0.59) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL5821878 | 0.81 | MAPT (0.55) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL6071233 | 0.81 | MAPT (0.55) | MAPTALDH1A1HTTGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4521422-A | ANTICONVULSANT, ANTIEPILEPTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS | AMERICAN CYANAMID COMPANY (US) | 1985-06-04 | — | — | US | disclosed |
| EP-0129847-A2 | Aryl and heteroaryl[7-(aryl and heteroaryl)-pyrazolo-[1,5-a]-pyrimidin-3-yl]methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | disclosed |