Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.71 |
| ▸ | PDE4A | P27815 | 13/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.71 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369703 | 0.82 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7359192 | 0.81 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7973484 | 0.79 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7368326 | 0.79 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL5704511 | 0.79 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7359776 | 0.79 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7367754 | 0.79 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7370525 | 0.77 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7360400 | 0.76 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL9580298 | 0.76 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563143-A | ANTIINFLAMMATORY AGENTS, AUTOIMMUNE DISORDERS | PFIZER INC. (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0706795-A2 | Catechol diether compounds as inhibitors of TNF release | PFIZER INC. (US) | 1996-04-17 | — | — | EP | disclosed |
| EP-0672031-A1 | CATECHOL DIETHERS AS SELECTIVE PDE IV? INHIBITORS | PFIZER INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994012461-A1 | CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS | PFIZER INC. (US) | 1994-06-09 | — | — | WO | disclosed |