Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.79 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | VEGFA | P15692 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PDE1A | P54750 | 1/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366110 | 0.89 | PDE4A (0.82) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| SCHEMBL3542641 | 0.89 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| SCHEMBL3541761 | 0.89 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| SCHEMBL5760778 | 0.89 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| Hydrochloric Acid SCHEMBL7365341 | 0.88 | PDE4A (0.80) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| SCHEMBL7448224 | 0.86 | PDE4A (0.83) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| SCHEMBL3543287 | 0.85 | PDE4A (0.82) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| SCHEMBL3548412 | 0.85 | PDE4A (0.82) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| SCHEMBL5214937 | 0.85 | PDE4A (0.82) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| SCHEMBL13016490 | 0.85 | PDE4A (0.82) | PDE4APDE4DPDE4BPDE4CCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993007141-A1 | HETEROCYCLIC 3-PHENYLPYRROLIDIN-2-ONES, THEIR PREPARATION AND USE FOR THE MANUFACTURE OF A MEDICAMENT FOR INHIBITING TUMOR NECROSIS FACTOR PRODUCTION | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-15 | — | — | WO | claimed |
| WO-1993007141-A1 | HETEROCYCLIC 3-PHENYLPYRROLIDIN-2-ONES, THEIR PREPARATION AND USE FOR THE MANUFACTURE OF A MEDICAMENT FOR INHIBITING TUMOR NECROSIS FACTOR PRODUCTION | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-15 | — | — | WO | disclosed |