Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.77 |
| ▸ | PDE6C | P51160 | 2/20 | 0.69 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.69 |
| ▸ | PDE6D | O43924 | 1/20 | 0.66 |
| ▸ | PDE6A | P16499 | 1/20 | 0.66 |
| ▸ | PDE6G | P18545 | 1/20 | 0.66 |
| ▸ | PDE6B | P35913 | 1/20 | 0.66 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8212467 | 0.96 | PDE5A (0.71) | PDE5APDE6CPDE11APDE6DPDE6A | |
| SCHEMBL7372999 | 0.92 | PDE5A (0.69) | PDE5APDE6CPDE11A | |
| SCHEMBL7378244 | 0.91 | PDE5A (0.70) | PDE5APDE6CPDE11APDE6DPDE6A | |
| SCHEMBL7373698 | 0.88 | PDE5A (0.72) | PDE5APDE6CPDE11A | |
| SCHEMBL7377912 | 0.88 | PDE5A (0.65) | PDE5APDE6CPDE11APDE6DPDE6A | |
| SCHEMBL688703 | 0.87 | PDE5A (1.00) | PDE5APDE6CPDE11APDE6DPDE6A | |
| SCHEMBL7373885 | 0.86 | PDE5A (0.71) | PDE5APDE6CPDE11APDE6DPDE6A | |
| SCHEMBL8206815 | 0.85 | PDE5A (0.58) | PDE5APDE6CPDE11A | |
| SCHEMBL7371213 | 0.84 | PDE5A (0.64) | PDE5APDE6CPDE11A | |
| SCHEMBL2563794 | 0.83 | PDE5A (0.81) | PDE5APDE6CPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1085871-A4 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL MYERS SQUIBB CO (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-1085871-A1 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-03-28 | — | — | EP | disclosed |
| US-6087368-A | AN ENZYME INHIBITOR TREATING ERECTILE DYSFUNCTION OF SEX DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-07-11 | — | — | US | disclosed |
| WO-1999064004-A1 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-16 | — | — | WO | disclosed |