Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP12 | P39900 | 2/20 | 0.42 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL198917 | 0.79 | KDM4E (0.59) | MAPTKDM4EKMT2AMEN1TSHR | |
| SCHEMBL9700707 | 0.78 | KDM4E (0.71) | MAPTKDM4EGAATHRBTDP1 | |
| SCHEMBL7365410 | 0.77 | MAPT (0.42) | MAPTKDM4EGAATHRBTDP1 | |
| SCHEMBL3349351 | 0.74 | KDM4E (0.49) | MAPTKDM4EGAATHRBTDP1 | |
| SCHEMBL15473215 | 0.74 | KMT2A (0.57) | MAPTKDM4EGAAKMT2AMEN1 | |
| SCHEMBL10966475 | 0.73 | CYP1A2 (0.50) | MAPTKDM4EGAATHRBTDP1 | |
| SCHEMBL9142230 | 0.73 | CLK4 (0.64) | MAPTKDM4EGAAKMT2AMEN1 | |
| 1,3-Dipropoxybenzene SCHEMBL73716 | 0.73 | KMT2A (0.63) | MAPTKDM4EKMT2ALMNATSHR | |
| SCHEMBL7410861 | 0.72 | PDE5A (0.47) | MAPTKDM4EKMT2AMEN1NOTUM | |
| SCHEMBL10965995 | 0.71 | MAPT (0.72) | MAPTKDM4EKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613467-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993010093-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-05-27 | — | — | WO | disclosed |