Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 3/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408485 | 0.81 | SLC6A4 (0.47) | SLC6A4SLC6A3SLC6A2HSD11B1HTR2A | |
| SCHEMBL16516607 | 0.80 | HDAC4 (0.40) | SLC6A4SLC6A3SLC6A2DPP4HSD11B1 | |
| SCHEMBL7047850 | 0.80 | SLC6A4 (0.51) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL3408732 | 0.78 | SLC6A4 (0.51) | SLC6A4SLC6A3SLC6A2HSD11B1HTR2A | |
| SCHEMBL7366122 | 0.77 | SLC6A4 (0.55) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL3413223 | 0.76 | SLC6A4 (0.54) | SLC6A4SLC6A3SLC6A2HSD11B1HTR2A | |
| SCHEMBL7371506 | 0.76 | SLC6A4 (0.52) | SLC6A4SLC6A3SLC6A2CYP1A2 | |
| SCHEMBL13107026 | 0.76 | SLC6A4 (0.46) | SLC6A4SLC6A3SLC6A2CCR2NPC1 | |
| SCHEMBL31375623 | 0.76 | SLC6A4 (0.46) | SLC6A4SLC6A3SLC6A2CCR2NPC1 | |
| SCHEMBL3406111 | 0.74 | SLC6A4 (0.42) | SLC6A4SLC6A3SLC6A2HSD11B1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715620-A1 | 1-ARYLCYCLOALKYL SULPHIDES, SULPHOXIDES AND SULPHONES FOR THE TREATMENT OF DEPRESSION, ANXIETY AND PARKINSON'S DISEASE | Knoll AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| WO-1994026704-A1 | 1-ARYLCYCLOALKYL SULPHIDES, SULPHOXIDES AND SULPHONES FOR THE TREATMENT OF DEPRESSION, ANXIETY AND PARKINSON'S DISEASE | THE BOOTS COMPANY PLC (GB) | 1994-11-24 | — | — | WO | disclosed |