Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | VEGFA | P15692 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PDE1A | P54750 | 1/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460808 | 0.82 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3261886 | 0.80 | PDE4B (0.77) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL14456035 | 0.79 | PDE4B (0.76) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL14193481 | 0.78 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL14456052 | 0.78 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL7364822 | 0.77 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL7366303 | 0.77 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL4465388 | 0.75 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL5327533 | 0.75 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL14456036 | 0.74 | PDE4B (0.61) | PDE4APDE4BPDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814651-A | PHOSPHODIESTERASE TYPE FOUR INHIBITORS | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |
| EP-0672031-A1 | CATECHOL DIETHERS AS SELECTIVE PDE IV? INHIBITORS | PFIZER INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994012461-A1 | CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS | PFIZER INC. (US) | 1994-06-09 | — | — | WO | disclosed |