Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.58 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CD38 | P28907 | 1/20 | 0.48 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370622 | 0.83 | MAPT (0.56) | MAPTL3MBTL1MAPK1KMT2AMEN1 | |
| SCHEMBL7374362 | 0.82 | MAPT (0.56) | MAPTL3MBTL1MAPK1KMT2AMEN1 | |
| SCHEMBL7374361 | 0.81 | MAPT (0.59) | MAPTL3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7373815 | 0.81 | CDK5 (0.53) | MAPTL3MBTL1MAPK1KMT2AMEN1 | |
| SCHEMBL9422885 | 0.78 | MAPT (0.66) | MAPTL3MBTL1MAPK1KMT2AMEN1 | |
| SCHEMBL9422922 | 0.78 | MAPT (0.66) | MAPTL3MBTL1MAPK1KMT2AMEN1 | |
| SCHEMBL7328985 | 0.77 | MAPT (1.00) | MAPTL3MBTL1MAPK1KMT2AMEN1 | |
| SCHEMBL23270782 | 0.76 | MAPT (0.71) | MAPTL3MBTL1MAPK1KMT2AMEN1 | |
| SCHEMBL7374301 | 0.76 | MAPT (0.53) | MAPTL3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7377328 | 0.76 | PDE5A (0.48) | MAPTL3MBTL1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1085871-A4 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL MYERS SQUIBB CO (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-1085871-A1 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-03-28 | — | — | EP | disclosed |
| US-6087368-A | AN ENZYME INHIBITOR TREATING ERECTILE DYSFUNCTION OF SEX DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-07-11 | — | — | US | disclosed |
| WO-1999064004-A1 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-16 | — | — | WO | disclosed |