Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.80 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.80 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.80 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.80 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7376577 | 0.88 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7395757 | 0.87 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6634116 | 0.84 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400689 | 0.80 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14455896 | 0.80 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7369182 | 0.79 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400362 | 0.79 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4DF2 | |
| SCHEMBL7401440 | 0.78 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL84865 | 0.78 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15490608 | 0.78 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837860-B1 | TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO(3,4-c]-1,2,4-TRIAZOLO(4,3-ALPHA]PYRIDINES | PFIZER (US) | 2002-03-20 | — | — | EP | disclosed |
| US-6004974-A | PHOSPHODIESTERASE AND TUMOR NECROSIS FACTOR INHIBITORS; ANTIINFLAMMATORY AND ANTIASTHMA AGENTS | PFIZER INC (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0837860-A1 | TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO 3,4-c]-1,2,4-TRIAZOLO 4,3-$g(a)]PYRIDINES | PFIZER INC. (US) | 1998-04-29 | — | — | EP | disclosed |
| WO-1996039408-A1 | TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO[3,4-c]-1,2,4-TRIAZOLO[4,3-α]PYRIDINES | PFIZER INC. (US) | 1996-12-12 | — | — | WO | disclosed |
| EP-0707585-A1 | BICYCLIC TETRAHYDRO PYRAZOLOPYRIDINES | PFIZER INC. (US) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001980-A1 | BICYCLIC TETRAHYDRO PYRAZOLOPYRIDINES | PFIZER INC. (US) | 1995-01-19 | — | — | WO | disclosed |