Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 7/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 8/20 | 0.41 |
| ▸ | MAOB | P27338 | 8/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370754 | 1.00 | SLC6A2 (0.45) | SLC6A2SLC6A4KDM1ABCHELMNA | |
| Hydrochloric Acid SCHEMBL8635679 | 0.99 | SLC6A2 (0.44) | SLC6A2SLC6A4KDM1ABCHELMNA | |
| Hydrochloric Acid SCHEMBL7377388 | 0.99 | SLC6A2 (0.44) | SLC6A2SLC6A4KDM1ABCHELMNA | |
| Hydrochloric Acid SCHEMBL8637062 | 0.99 | SLC6A2 (0.44) | SLC6A2SLC6A4KDM1ABCHELMNA | |
| Hydrochloric Acid SCHEMBL7375620 | 0.99 | SLC6A2 (0.44) | SLC6A2SLC6A4KDM1ABCHELMNA | |
| SCHEMBL7374725 | 0.88 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7373040 | 0.87 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3L3MBTL1 | |
| SCHEMBL7370489 | 0.85 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL7370002 | 0.84 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL7369999 | 0.84 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711272-A1 | INDANE AND TETRAHYDRONAPHTHALENE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-15 | — | — | EP | claimed |
| WO-1995004028-A1 | INDANE AND TETRAHYDRONAPHTHALENE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-02-09 | — | — | WO | claimed |
| US-5773463-A | DECALCIFICATION OF BRAIN DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-06-30 | — | — | US | disclosed |
| EP-0711272-A1 | INDANE AND TETRAHYDRONAPHTHALENE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004028-A1 | INDANE AND TETRAHYDRONAPHTHALENE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-02-09 | — | — | WO | disclosed |