Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 9/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1063404 | 0.80 | CYP2C19 (0.40) | MMEEPHX1CYP2C19 | |
| SCHEMBL7378420 | 0.78 | MME (0.35) | MMEEPHX1CYP2C19L3MBTL1 | |
| SCHEMBL11295589 | 0.77 | EPHX1 (0.40) | EPHX1CYP2C19L3MBTL1CYP2C9ALDH1A1 | |
| SCHEMBL3587680 | 0.76 | SMN1; SMN2 (0.42) | MMECYP2C19L3MBTL1CYP2C9ALDH1A1 | |
| SCHEMBL15519662 | 0.75 | NPSR1 (0.43) | CYP2C19L3MBTL1ALDH1A1 | |
| SCHEMBL12822139 | 0.75 | NPSR1 (0.43) | CYP2C19L3MBTL1ALDH1A1 | |
| SCHEMBL988593 | 0.74 | CYP1A2 (0.38) | CYP2C19ALDH1A1 | |
| SCHEMBL24874106 | 0.73 | MME (0.43) | MMEEPHX1CYP2C19L3MBTL1CYP2C9 | |
| SCHEMBL11300362 | 0.73 | CETP (0.47) | MMEEPHX1CYP2C19L3MBTL1CYP2C9 | |
| SCHEMBL11291527 | 0.73 | CETP (0.47) | MMEEPHX1CYP2C19L3MBTL1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5095137-A | Hypotensives | LABORATORI GUIDOTTI SPA (IT) | 1992-03-10 | — | — | US | disclosed |
| EP-0337348-A2 | Amides of cyclomethylen-1,2-bicarboxylic acids having therapeutical activity, processes for their preparation and pharmaceutical compositions containing them | Laboratori Guidotti S.p.A. (IT) | 1989-10-18 | — | — | EP | disclosed |