Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367374 | 0.83 | HPGD (0.48) | MAPK8HPGDLMNASMN1; SMN2 | |
| SCHEMBL4825983 | 0.82 | MAPK8 (0.53) | MAPK8HPGDLMNASMN1; SMN2 | |
| SCHEMBL7370502 | 0.82 | MAPK8 (0.62) | MAPK8HPGDLMNASMN1; SMN2 | |
| SCHEMBL7365815 | 0.81 | MAPK8 (0.56) | MAPK8HPGDLMNASMN1; SMN2 | |
| SCHEMBL7370846 | 0.81 | MAPK8 (0.52) | MAPK8HPGDLMNASMN1; SMN2GAA | |
| SCHEMBL7373017 | 0.80 | MAPK8 (0.60) | MAPK8HPGDLMNASMN1; SMN2GAA | |
| SCHEMBL7366732 | 0.80 | HPGD (0.61) | MAPK8HPGDLMNASMN1; SMN2 | |
| SCHEMBL7367596 | 0.80 | PDE4A (0.54) | MAPK8HPGDLMNASMN1; SMN2 | |
| SCHEMBL5362716 | 0.80 | PDE4A (0.60) | MAPK8HPGDLMNASMN1; SMN2 | |
| SCHEMBL7366923 | 0.80 | AURKA (0.43) | MAPK8GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |