Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 13/20 | 0.51 |
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370536 | 1.00 | MAOB (0.51) | MAOBMAOAOPRL1KCNH2NR4A2 | |
| SCHEMBL1346598 | 0.89 | MAOB (0.50) | MAOBMAOAKCNH2NR4A2 | |
| SCHEMBL1345209 | 0.89 | MAOB (0.50) | MAOBMAOAKCNH2NR4A2 | |
| SCHEMBL7370303 | 0.88 | MAOB (0.50) | MAOBMAOA | |
| SCHEMBL7371960 | 0.88 | FFAR1 (0.50) | MAOBMAOAPARP10 | |
| SCHEMBL1346673 | 0.83 | MAOB (0.48) | MAOBMAOAKCNH2NR4A2SCN3A | |
| SCHEMBL7369966 | 0.83 | MAOB (0.48) | MAOBMAOAKCNH2NR4A2SCN3A | |
| SCHEMBL7372317 | 0.82 | KDM4E (0.51) | MAOBMAOAKCNH2SCN3A | |
| SCHEMBL1346165 | 0.82 | KDM4E (0.51) | MAOBMAOAKCNH2SCN3A | |
| SCHEMBL7378367 | 0.82 | FFAR1 (0.48) | MAOBMAOAPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842152-B1 | N-(4-SUBSTITUTED-BENZYL)-2-AMINOLACTAM DERIVATIVES | NEWRON PHARM SPA (IT) | 2001-01-31 | — | — | EP | disclosed |
| US-5912242-A | ANTIEPILEPTIC, ANTI-PARKINSON, ANTIDEPRESSANT, ANTISPASMODIC, NEUROPROTECTIVE OR HYPNOTIC AGENTS, FOR TREATMENT OF NEURODEGENERATIVE DISEASES | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-15 | — | — | US | disclosed |
| EP-0842152-A1 | N-(4-SUBSTITUTED-BENZYL)-2-AMINOLACTAM DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997005111-A1 | N-(4-SUBSTITUTED-BENZYL)-2-AMINOLACTAM DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-02-13 | — | — | WO | disclosed |