Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | BRAF | P15056 | 13/20 | 0.56 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.53 |
| ▸ | GSK3A | P49840 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7400081 | 0.89 | KDM4E (0.70) | KDM4EBRAFTLR8 | |
| SCHEMBL10942042 | 0.89 | KDM4E (0.68) | KDM4EBRAFTLR8 | |
| SCHEMBL7362754 | 0.85 | KDM4E (0.68) | KDM4EBRAFTLR8GSK3AEPHA2 | |
| SCHEMBL3172240 | 0.84 | KDM4E (0.80) | KDM4EBRAFTLR8 | |
| SCHEMBL3175469 | 0.83 | KDM4E (0.83) | KDM4EBRAFTLR8 | |
| SCHEMBL7369186 | 0.83 | KDM4E (0.72) | KDM4EBRAFTLR8 | |
| SCHEMBL7360041 | 0.83 | KDM4E (0.75) | KDM4EBRAFTLR8 | |
| SCHEMBL7398348 | 0.83 | KDM4E (0.68) | KDM4EBRAFTLR8 | |
| SCHEMBL7394656 | 0.83 | MAP2K1 (0.51) | KDM4ETLR8GSK3ACDK1PIM1 | |
| SCHEMBL11464152 | 0.82 | KDM4E (0.81) | KDM4EBRAFTLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4521422-A | ANTICONVULSANT, ANTIEPILEPTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS | AMERICAN CYANAMID COMPANY (US) | 1985-06-04 | — | — | US | disclosed |
| EP-0129847-A2 | Aryl and heteroaryl[7-(aryl and heteroaryl)-pyrazolo-[1,5-a]-pyrimidin-3-yl]methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | disclosed |