Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370502 | 0.94 | MAPK8 (0.62) | MAPK8KMT2AKDM4EMEN1CYP1A2 | |
| SCHEMBL7677451 | 0.90 | MAPK8 (0.57) | MAPK8KMT2AHPGDLMNASMN1; SMN2 | |
| SCHEMBL7403963 | 0.90 | MAPK8 (0.59) | MAPK8KMT2AKDM4EMEN1CYP1A2 | |
| SCHEMBL7373017 | 0.89 | MAPK8 (0.60) | MAPK8KMT2AHPGDLMNASMN1; SMN2 | |
| SCHEMBL7366732 | 0.89 | HPGD (0.61) | MAPK8KMT2AMEN1HPGDLMNA | |
| SCHEMBL7373774 | 0.88 | MAPK8 (0.62) | MAPK8KMT2AKDM4EMEN1CYP1A2 | |
| SCHEMBL7370229 | 0.88 | MAPK8 (0.55) | MAPK8KMT2AHPGDHDAC6LMNA | |
| SCHEMBL7405957 | 0.87 | MAPK8 (0.54) | MAPK8KMT2AHPGDHDAC6LMNA | |
| SCHEMBL7372559 | 0.87 | MAPK8 (0.58) | MAPK8KMT2AMEN1HPGDLMNA | |
| SCHEMBL7399781 | 0.86 | MAPK8 (0.57) | MAPK8KMT2AHPGDLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |