Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.65 |
| ▸ | HTR2C | P28335 | 1/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | HTR2B | P41595 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.65 |
| ▸ | DRD4 | P21917 | 13/20 | 0.56 |
| ▸ | CCR3 | P51677 | 1/20 | 0.51 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368823 | 0.93 | DRD3 (0.76) | DRD3CYP1A2CYP3A4CYP2C9MEN1 | |
| SCHEMBL31356433 | 0.93 | DRD3 (0.76) | DRD3CYP1A2CYP3A4CYP2C9MEN1 | |
| SCHEMBL7365175 | 0.93 | DRD3 (0.63) | DRD3CYP1A2CYP3A4CYP2C9MEN1 | |
| SCHEMBL7366109 | 0.91 | DRD3 (0.59) | DRD3CYP1A2CYP3A4CYP2C9MEN1 | |
| SCHEMBL7370227 | 0.91 | DRD3 (0.61) | DRD3CYP1A2CYP3A4CYP2C9MEN1 | |
| SCHEMBL7372947 | 0.88 | DRD3 (0.64) | DRD3CYP1A2CYP3A4CYP2C9MEN1 | |
| SCHEMBL7369152 | 0.87 | DRD3 (0.57) | DRD3CYP1A2CYP3A4CYP2C9MEN1 | |
| SCHEMBL7371848 | 0.87 | DRD3 (0.57) | DRD3CYP1A2CYP3A4CYP2C9MEN1 | |
| SCHEMBL7370724 | 0.85 | DRD3 (0.59) | DRD3CYP1A2CYP3A4CYP2C9MEN1 | |
| SCHEMBL15827623 | 0.81 | DRD3 (0.50) | DRD3CYP1A2CYP3A4CYP2C9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243959-B1 | SUBSTITUTED BENZAMIDE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1992-08-19 | — | — | EP | disclosed |
| US-4870074-A | Substituted benzamide derivatives, for enhancing gastrointestinal motility | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1989-09-26 | — | — | US | disclosed |
| EP-0243959-A1 | Substituted benzamide derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same | Dainippon Pharmaceutical Co., Ltd. (JP) | 1987-11-04 | — | — | EP | disclosed |