Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 5/20 | 0.57 |
| ▸ | F10 | P00742 | 5/20 | 0.57 |
| ▸ | F7 | P08709 | 3/20 | 0.57 |
| ▸ | PLAU | P00749 | 7/20 | 0.51 |
| ▸ | PLG | P00747 | 6/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.50 |
| ▸ | PLAT | P00750 | 2/20 | 0.49 |
| ▸ | MPL | P40238 | 1/20 | 0.49 |
| ▸ | CBFB | Q13951 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7405923 | 0.92 | F2 (0.47) | F2F10F7PLAUPLG | |
| SCHEMBL23793905 | 0.80 | F2 (0.50) | F2F10F7PLAUPLG | |
| Hydrochloric Acid SCHEMBL28577597 | 0.79 | F2 (0.49) | F2F10F7PLAUPLG | |
| Hydrochloric Acid SCHEMBL30882325 | 0.79 | F2 (0.49) | F2F10F7PLAUPLG | |
| SCHEMBL11453513 | 0.78 | NPC1 (0.51) | HDAC6CBFB | |
| SCHEMBL7373376 | 0.76 | F10 (0.46) | F2F10PLAUPLGPRSS1 | |
| SCHEMBL14519373 | 0.74 | PLAU (0.73) | F2F10F7PLAUPLG | |
| SCHEMBL14519400 | 0.74 | CHEK2 (0.68) | F2F10F7PLAUPLG | |
| SCHEMBL29361810 | 0.74 | F10 (0.70) | F2F10F7PLAUPLG | |
| SCHEMBL5394696 | 0.74 | PLAU (0.68) | F2F10F7PLAUPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150379-A | BLOOD COAGULATION FACTOR XA INHIBITORS; TREATING DISEASES ASSOCIATED WITH SERINE PROTEASE ACTIVITY; THROMBOLYTIC AND ISCHEMIC AGENTS; E.G., 2-(6-(5-AMIDINO-1H-BENZIMIDAZOL-2-YL)-PYRID-3-YLCARBONYLAMINO)-3 -HYDROXYBUTYRIC ACID | AXYS PHARMACEUTICALS, INC. (US) | 2000-11-21 | — | — | US | disclosed |
| WO-1999026941-A1 | SUBSTITUTED AMIDINOARYL DERIVATIVES AND THEIR USE AS ANTICOAGULANTS | AXYS PHARMACEUTICALS, INC. (US) | 1999-06-03 | — | — | WO | disclosed |