Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.47 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GALR3 | O60755 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5677201 | 0.86 | PDE3B (0.48) | PDE3BPDE3ATNNC1MAPTSMN1; SMN2 | |
| SCHEMBL5681007 | 0.86 | PDE3B (0.48) | PDE3BPDE3ATNNC1MAPTSMN1; SMN2 | |
| SCHEMBL5677182 | 0.86 | PDE3B (0.48) | PDE3BPDE3ATNNC1MAPTSMN1; SMN2 | |
| SCHEMBL5677191 | 0.86 | PDE3B (0.48) | PDE3BPDE3ATNNC1MAPTSMN1; SMN2 | |
| SCHEMBL5676841 | 0.82 | PDE3B (0.52) | PDE3BPDE3ATNNC1MAPTSMN1; SMN2 | |
| SCHEMBL5676837 | 0.82 | PDE3B (0.52) | PDE3BPDE3ATNNC1MAPTSMN1; SMN2 | |
| SCHEMBL7371494 | 0.81 | PDE3B (0.52) | PDE3BPDE3ATNNC1MAPTSMN1; SMN2 | |
| SCHEMBL7375687 | 0.80 | PDE3B (0.53) | PDE3BPDE3ATNNC1MAPTSMN1; SMN2 | |
| SCHEMBL7377597 | 0.80 | PDE3B (0.53) | PDE3BPDE3ATNNC1MAPTSMN1; SMN2 | |
| SCHEMBL5679128 | 0.79 | PDE3B (0.52) | PDE3BPDE3ATNNC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265871-A1 | PYRIDAZINYL PHENYL HYDRAZONES USEFUL AGAINST CONGESTIVE HEART FAILURE | ORION CORPORATION (FI) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001068611-A1 | PYRIDAZINYL PHENYL HYDRAZONES USEFUL AGAINST CONGESTIVE HEART FAILURE | ORION CORPORATION (FI) | 2001-09-20 | — | — | WO | disclosed |