Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ACE | P12821 | 9/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.54 |
| ▸ | DPP4 | P27487 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373956 | 0.93 | KMT2A (0.65) | KMT2AACEACE2DPP4CHRM2 | |
| SCHEMBL7380774 | 0.85 | ACE (0.59) | KMT2AACEACE2CHRM2CHRM4 | |
| SCHEMBL11545165 | 0.82 | ACE (0.53) | ACEACE2DPP4CHRM2CHRM4 | |
| SCHEMBL11162378 | 0.82 | ACE (0.61) | ACEACE2DPP4CHRM2CHRM4 | |
| SCHEMBL7386490 | 0.81 | ACE (0.57) | ACEACE2DPP4CHRM2CHRM4 | |
| SCHEMBL16967407 | 0.79 | ACE (0.54) | ACE | |
| SCHEMBL11153893 | 0.79 | PREP (0.67) | ACEACE2DPP4CHRM2CHRM4 | |
| SCHEMBL5741652 | 0.78 | MEN1 (0.63) | KMT2AACEACE2CHRM2CHRM4 | |
| Water SCHEMBL5570206 | 0.78 | ACE (0.52) | ACE | |
| SCHEMBL7330019 | 0.78 | MEN1 (0.63) | KMT2AACEACE2CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154840-A | Antihypertensive pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |
| US-4046889-A | HYPOTENSIVE AGENTS, ENZYME INHIBITORS, ANGIOTENSIN CONVERSION | E. R. SQUIBB & SONS, INC. (US) | 1977-09-06 | — | — | US | disclosed |