Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 15/20 | 0.63 |
| ▸ | CTSG | P08311 | 1/20 | 0.52 |
| ▸ | CMA1 | P23946 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8150682 | 1.00 | ELANE (0.63) | ELANECTSGCMA1 | |
| SCHEMBL8672185 | 1.00 | ELANE (0.63) | ELANECTSGCMA1 | |
| SCHEMBL7379996 | 1.00 | ELANE (0.63) | ELANECTSGCMA1 | |
| SCHEMBL8674112 | 1.00 | ELANE (0.63) | ELANECTSGCMA1 | |
| SCHEMBL5801511 | 1.00 | ELANE (0.63) | ELANECTSGCMA1 | |
| SCHEMBL8136651 | 1.00 | ELANE (0.63) | ELANECTSGCMA1 | |
| SCHEMBL8145232 | 1.00 | ELANE (0.63) | ELANECTSGCMA1 | |
| SCHEMBL7374559 | 1.00 | ELANE (0.63) | ELANECTSGCMA1 | |
| SCHEMBL7552455 | 1.00 | ELANE (0.63) | ELANECTSGCMA1 | |
| Water SCHEMBL5803036 | 0.99 | ELANE (0.62) | ELANECTSGCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808327-A1 | PROLINE DERIVATIVES USEFUL AS INHIBITORS OF HUMAN LEUKOCYTE ELASTASE | ZENECA LIMITED (GB) | 1997-11-26 | — | — | EP | claimed |
| US-5686628-A | Proline derivatives | ZENECA LTD. (GB) | 1997-11-11 | — | — | US | claimed |
| WO-1996023812-A1 | PROLINE DERIVATIVES USEFUL AS INHIBITORS OF HUMAN LEUKOCYTE ELASTASE | ZENECA LIMITED (GB) | 1996-08-08 | — | — | WO | claimed |
| US-6054593-A | Proline derivatives | ZENECA LIMITED (GB) | 2000-04-25 | — | — | US | disclosed |
| US-6048889-A | Proline derivatives | ZENECA LIMITED (GB) | 2000-04-11 | — | — | US | disclosed |
| US-5808097-A | OXIDATION OF THE CORRESPONDING HYDROXY COMPOUND | ZENECA LIMITED (GB) | 1998-09-15 | — | — | US | disclosed |
| US-5686628-A | Proline derivatives | ZENECA LTD. (GB) | 1997-11-11 | — | — | US | disclosed |