SCHEMBL7374151

SCHEMBL7374151

CSc1ccc(-c2nc3n(c2-c2ccncc2)CCS3)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 14/20 0.71
MAPK13 O15264 8/20 0.71
MAPK12 P53778 8/20 0.71
MAPK11 Q15759 8/20 0.71
KDM4E B2RXH2 1/20 0.70
CYP3A4 P08684 1/20 0.70
HPGD P15428 1/20 0.70
ALOX15 P16050 1/20 0.70
SMN1; SMN2 Q16637 1/20 0.70
HSD17B10 Q99714 1/20 0.70
TDP1 Q9NUW8 1/20 0.70
GCGR P47871 4/20 0.49
TGFBR1 P36897 1/20 0.47
PTGS1 P23219 2/20 0.39
PTGS2 P35354 2/20 0.39
PRKD3 O94806 1/20 0.39
MAP4K4 O95819 1/20 0.39
LCK P06239 1/20 0.39
RET P07949 1/20 0.39
ALOX5 P09917 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7369791 1.00 MAPK14 (0.71) MAPK14MAPK13MAPK12MAPK11KDM4E
SCHEMBL11384969 0.94 MAPK14 (0.60) MAPK14MAPK13MAPK12MAPK11KDM4E
SCHEMBL9297757 0.93 MAPK14 (0.61) MAPK14MAPK13MAPK12MAPK11KDM4E
Bromide SCHEMBL11374617 0.92 MAPK14 (0.59) MAPK14MAPK13MAPK12MAPK11KDM4E
SCHEMBL9436245 0.88 MAPK14 (0.84) MAPK14MAPK13MAPK12MAPK11KDM4E
SCHEMBL11502671 0.86 MAPK14 (0.76) MAPK14MAPK13MAPK12MAPK11KDM4E
SCHEMBL146947 0.83 MAPK14 (1.00) MAPK14MAPK13MAPK12MAPK11KDM4E
SCHEMBL7378916 0.83 MAPK14 (1.00) MAPK14MAPK13MAPK12MAPK11KDM4E
SCHEMBL9748155 0.83 MAPK14 (0.76) MAPK14MAPK13MAPK12MAPK11KDM4E
SCHEMBL9343464 0.82 MAPK14 (0.71) MAPK14MAPK13MAPK12MAPK11KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1990015534-A1 MONOKINE ACTIVITY INTERFERENCE SMITHKLINE BEECHAM CORPORATION (US) 1990-12-27 WO claimed
EP-0321490-B1 INHIBITION OF INTERLEUKIN-1 PRODUCTION BY MONOCYTES AND/OR MACROPHAGES SMITHKLINE BEECHAM CORP (US) 1994-06-22 EP disclosed
US-5317019-A Antiinflammatory agents SMITHKLINE BEECHAM CORP. (US) 1994-05-31 US disclosed
EP-0411754-A2 Medicament for the inhibition of interleukin-1 or tumor necrosis factor production by monocytes and/or macrophages SMITHKLINE BEECHAM CORPORATION (US) 1991-02-06 EP disclosed
WO-1991000092-A1 INHIBITION OF INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR PRODUCTION BY MONOCYTES AND/OR MACROPHAGES SMITHKLINE BEECHAM CORPORATION (US) 1991-01-10 WO disclosed
WO-1990015534-A1 MONOKINE ACTIVITY INTERFERENCE SMITHKLINE BEECHAM CORPORATION (US) 1990-12-27 WO disclosed
EP-0403251-A2 Monokine activity interference SMITHKLINE BEECHAM CORPORATION (US) 1990-12-19 EP disclosed
EP-0321490-A4 INHIBITION OF INTERLEUKIN-1 PRODUCTION BY MONOCYTES AND/OR MACROPHAGES. SMITHKLINE BECKMAN CORP (US) 1990-05-14 EP disclosed
EP-0321490-A1 INHIBITION OF INTERLEUKIN-1 PRODUCTION BY MONOCYTES AND/OR MACROPHAGES. SMITHKLINE BECKMAN CORP (US) 1989-06-28 EP disclosed
WO-1988001169-A1 INHIBITION OF INTERLEUKIN-1 PRODUCTION BY MONOCYTES AND/OR MACROPHAGES SMITHKLINE BECKMAN CORPORATION (US) 1988-02-25 WO disclosed
US-4175127-A ANTIARTHRITIC AGENTS SMITHKLINE CORPORATION (US) 1979-11-20 US disclosed