Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 17/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6637350 | 0.78 | PDE4A (0.47) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL6638544 | 0.71 | PDE4A (0.54) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL7369320 | 0.71 | PDE4A (0.48) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL14028559 | 0.69 | PDE4A (0.45) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL7376901 | 0.66 | PDE4A (0.65) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL210263 | 0.66 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL7395757 | 0.65 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL6839751 | 0.65 | PDE4A (0.79) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL14455896 | 0.65 | PDE4A (0.84) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL7374697 | 0.64 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4CADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837860-B1 | TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO(3,4-c]-1,2,4-TRIAZOLO(4,3-ALPHA]PYRIDINES | PFIZER (US) | 2002-03-20 | — | — | EP | disclosed |
| US-6004974-A | PHOSPHODIESTERASE AND TUMOR NECROSIS FACTOR INHIBITORS; ANTIINFLAMMATORY AND ANTIASTHMA AGENTS | PFIZER INC (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0837860-A1 | TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO 3,4-c]-1,2,4-TRIAZOLO 4,3-$g(a)]PYRIDINES | PFIZER INC. (US) | 1998-04-29 | — | — | EP | disclosed |
| WO-1996039408-A1 | TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO[3,4-c]-1,2,4-TRIAZOLO[4,3-α]PYRIDINES | PFIZER INC. (US) | 1996-12-12 | — | — | WO | disclosed |