Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.58 |
| ▸ | MTOR | P42345 | 6/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.47 |
| ▸ | ATR | Q13535 | 8/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 8/20 | 0.47 |
| ▸ | ATRIP | Q8WXE1 | 8/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 8/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3602834 | 0.89 | PIK3CA (0.61) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL739763 | 0.87 | PIK3CA (0.71) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL738650 | 0.85 | PIK3CA (0.72) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL3594578 | 0.85 | PIK3CA (0.61) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL737885 | 0.84 | PIK3CA (0.74) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL737933 | 0.84 | PIK3CA (0.83) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL738315 | 0.84 | PIK3CA (0.68) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL3591707 | 0.84 | PIK3CD (0.59) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL13283656 | 0.83 | PIK3CA (0.59) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL11898425 | 0.83 | PIK3CA (0.59) | PIK3CAPIK3CDMTORCHEK1ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176238-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2012-04-18 | — | — | EP | disclosed |
| US-8138183-B2 | Morpholino pyrimidine derivatives used in diseases linked to mTOR kinase and/or PI3K | ASTRAZENECA AB (SE) | 2012-03-20 | — | — | US | disclosed |
| US-8138183-B2 | Morpholino pyrimidine derivatives used in diseases linked to mTOR kinase and/or PI3K | ASTRAZENECA AB (SE) | 2012-03-20 | — | — | US | disclosed |
| US-8138183-B2 | Morpholino pyrimidine derivatives used in diseases linked to mTOR kinase and/or PI3K | ASTRAZENECA AB (SE) | 2012-03-20 | — | — | US | disclosed |
| US-20100249131-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2010-09-30 | — | — | US | disclosed |
| US-20100249131-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2010-09-30 | — | — | US | disclosed |
| US-20100249131-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2010-09-30 | — | — | US | disclosed |
| WO-2009007750-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249131-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | PIK3CA, MTOR, PIK3CD | PIK3CA 1/4885PIK3CD 3/4885MTOR 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.