Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | PI4KA | P42356 | 2/20 | 0.53 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.53 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | XDH | P47989 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.48 |
| ▸ | G6PD | P11413 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11415127 | 0.81 | HIF1A (0.54) | HIF1API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL7375286 | 0.81 | HSD17B10 (0.55) | HIF1API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL30925386 | 0.77 | HIF1A (0.61) | HIF1API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9350406 | 0.75 | DPP4 (0.59) | HSD17B10CYP1A2CYP2C19PDPK1CDK2 | |
| SCHEMBL5998976 | 0.75 | HIF1A (0.48) | HIF1API4KAPI4K2BPI4K2API4KB | |
| Adenine SCHEMBL40371 | 0.73 | PI4KA (0.79) | HIF1API4KAPI4K2BPI4K2API4KB | |
| Adenine SCHEMBL29546720 | 0.73 | PI4KA (0.79) | HIF1API4KAPI4K2BPI4K2API4KB | |
| Adenine SCHEMBL30565251 | 0.73 | PI4KA (0.79) | HIF1API4KAPI4K2BPI4K2API4KB | |
| Adenine SCHEMBL6308303 | 0.71 | PI4KA (0.76) | HIF1API4KAPI4K2BPI4K2API4KB | |
| Adenine SCHEMBL8426318 | 0.71 | PI4KA (0.79) | HIF1API4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977169-A | FOR TREATMENT OF A PERSON WITH AIDS OR AIDS RELATED DISEASES | PHARMACIA & UPJOHN COMPANY | 1999-11-02 | — | — | US | claimed |
| EP-0720607-A1 | SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 1996-07-10 | — | — | EP | claimed |
| WO-1995007901-A1 | SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1995-03-23 | — | — | WO | claimed |
| US-5977169-A | FOR TREATMENT OF A PERSON WITH AIDS OR AIDS RELATED DISEASES | PHARMACIA & UPJOHN COMPANY | 1999-11-02 | — | — | US | disclosed |
| EP-0720607-A1 | SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995007901-A1 | SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1995-03-23 | — | — | WO | disclosed |