Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 5/20 | 0.42 |
| ▸ | CA2 | P00918 | 5/20 | 0.42 |
| ▸ | CA9 | Q16790 | 5/20 | 0.42 |
| ▸ | SUCNR1 | Q9BXA5 | 6/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375525 | 1.00 | CA12 (0.42) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL7379826 | 0.94 | CA12 (0.41) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL7379828 | 0.94 | CA12 (0.41) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL7215515 | 0.79 | CA12 (0.51) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL7222259 | 0.76 | CA12 (0.47) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL7218211 | 0.76 | CA12 (0.53) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL7217990 | 0.73 | CA12 (0.49) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL7215538 | 0.70 | SUCNR1 (0.40) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL7222276 | 0.69 | CA12 (0.43) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL7222270 | 0.69 | CA12 (0.43) | CA12CA1CA2CA9SUCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115724-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | Shire Biochem Inc. (CA) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017197-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | BIOCHEM PHARMA INC. (US) | 2000-03-30 | — | — | WO | disclosed |