Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | RORA | P35398 | 1/20 | 0.44 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7376263 | 1.00 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL6557216 | 0.84 | FFAR1 (0.50) | ALDH1A1 | |
| SCHEMBL27396740 | 0.84 | FFAR1 (0.50) | ALDH1A1 | |
| SCHEMBL27999258 | 0.83 | GAA (0.58) | NPC1RAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL5954163 | 0.79 | ELANE (0.47) | SMN1; SMN2ALDH1A1CA12CA1CA2 | |
| SCHEMBL5954162 | 0.79 | ELANE (0.47) | SMN1; SMN2ALDH1A1CA12CA1CA2 | |
| SCHEMBL7373973 | 0.78 | MAPT (0.55) | SMN1; SMN2HPGDALDH1A1POLBGAA | |
| SCHEMBL6555717 | 0.78 | CA12 (0.54) | SMN1; SMN2ALDH1A1GAAMAPTCA12 | |
| SCHEMBL6555720 | 0.78 | CA12 (0.54) | SMN1; SMN2ALDH1A1GAAMAPTCA12 | |
| SCHEMBL16197782 | 0.78 | GAA (0.49) | RAB9ASMN1; SMN2HPGDALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399628-B1 | ALZHEIMER'S DISEASE | ATHENA NEUROSCIENCES, INC. | 2002-06-04 | — | — | US | claimed |
| US-6399628-B1 | ALZHEIMER'S DISEASE | ATHENA NEUROSCIENCES, INC. | 2002-06-04 | — | — | US | disclosed |
| US-5965614-A | A PEPTIDE BLOCKING AGENT FOR TREATING ALZHEIMER'S DISEASE | ATHENA NEUROSCIENCES, INC. | 1999-10-12 | — | — | US | disclosed |
| EP-0944580-A2 | N-(ARYL/HETEROARYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | Elan Pharmaceuticals, Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998022441-A2 | N-(ARYL/HETEROARYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE AND/OR ITS SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1998-05-28 | — | — | WO | disclosed |