Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373829 | 0.93 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7379736 | 0.92 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7734270 | 0.92 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL7738907 | 0.92 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7734205 | 0.92 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL7206477 | 0.91 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7381288 | 0.89 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DDRD4 | |
| SCHEMBL7738942 | 0.89 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7742229 | 0.89 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL7742150 | 0.88 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002541078-A | — | — | 2002-12-03 | — | — | JP | claimed |
| EP-1169321-A4 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | EURO CELTIQUE SA (LU) | 2002-10-30 | — | — | EP | claimed |
| US-6413975-B1 | DISEASES WITH HIGH LEVELS OF INFLAMMATORY CYTOKINES; ASTHMA; ALLERGIES; INFLAMMATION; DEPRESSION; ALZHEIMER'S DISEASE; VASCULAR AND MULTI-IN-FARCT DEMENTIA | EURO-CELTIQUE, S.A. (LU) | 2002-07-02 | — | — | US | claimed |
| EP-1169321-A2 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | Euro-Celtique S.A. (LU) | 2002-01-09 | — | — | EP | claimed |
| WO-2000059449-A2 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | EURO-CELTIQUE S.A. (LU) | 2000-10-12 | — | — | WO | claimed |
| US-6413975-B1 | DISEASES WITH HIGH LEVELS OF INFLAMMATORY CYTOKINES; ASTHMA; ALLERGIES; INFLAMMATION; DEPRESSION; ALZHEIMER'S DISEASE; VASCULAR AND MULTI-IN-FARCT DEMENTIA | EURO-CELTIQUE, S.A. (LU) | 2002-07-02 | — | — | US | disclosed |