Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.39 |
| ▸ | REN | P00797 | 4/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PEPD | P12955 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373401 | 0.84 | ACE (0.40) | ACERENKLK5HSD17B10POLB | |
| SCHEMBL7380815 | 0.81 | ACE (0.58) | ACERENHSD17B10PEPDKDM4E | |
| SCHEMBL7376742 | 0.81 | HSD17B10 (0.40) | ACEKLK5HSD17B10PEPDLMNA | |
| SCHEMBL26724941 | 0.78 | KLK5 (0.47) | ACERENKLK5HSD17B10POLB | |
| SCHEMBL11124849 | 0.77 | ACE (0.68) | ACERENKLK5HSD17B10POLB | |
| SCHEMBL11124851 | 0.77 | ACE (0.68) | ACERENKLK5HSD17B10POLB | |
| SCHEMBL15223614 | 0.76 | ACE (0.49) | ACERENHSD17B10POLBPEPD | |
| SCHEMBL10667535 | 0.76 | HSD17B10 (0.47) | KLK5HSD17B10POLBLMNAROCK2 | |
| SCHEMBL7886209 | 0.76 | HSD17B10 (0.47) | KLK5HSD17B10POLBLMNAROCK2 | |
| SCHEMBL14426644 | 0.76 | HSD17B10 (0.47) | KLK5HSD17B10POLBLMNAROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154840-A | Antihypertensive pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |
| US-4046889-A | HYPOTENSIVE AGENTS, ENZYME INHIBITORS, ANGIOTENSIN CONVERSION | E. R. SQUIBB & SONS, INC. (US) | 1977-09-06 | — | — | US | disclosed |