Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 13/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.57 |
| ▸ | PDE4A | P27815 | 10/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.57 |
| ▸ | BRD4 | O60885 | 2/20 | 0.52 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274403 | 0.83 | PDE3B (0.53) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7434895 | 0.81 | PDE3B (0.58) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7372300 | 0.76 | PDE3B (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7267003 | 0.73 | PDE4A (0.52) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7273826 | 0.73 | PDE4A (0.52) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7267795 | 0.73 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL3440910 | 0.73 | PDE3B (0.62) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7268219 | 0.72 | PDE3B (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7267391 | 0.72 | PDE3B (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7274243 | 0.72 | PDE3B (0.61) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381374-A1 | Phosphodiesterase inhibitors | LES LABORATOIRES BEECHAM S.A. (FR) | 1990-08-08 | — | — | EP | claimed |
| JP-2288875-A | — | — | None | — | — | JP | disclosed |
| JP-H02288875-A | NEW COMPOUND, ITS PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | LAB BEECHAM SA | 1990-11-28 | — | — | JP | disclosed |
| EP-0381374-A1 | Phosphodiesterase inhibitors | LES LABORATOIRES BEECHAM S.A. (FR) | 1990-08-08 | — | — | EP | disclosed |