Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 13/20 | 0.60 |
| ▸ | MAPT | P10636 | 13/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.60 |
| ▸ | GAA | P10253 | 11/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.58 |
| ▸ | HTT | P42858 | 8/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6920335 | 0.99 | PLAU (0.60) | PLAUMEN1MAPTKMT2AGAA | |
| Bromide SCHEMBL7823820 | 0.92 | PLAU (0.59) | PLAUMEN1MAPTKMT2AGAA | |
| Bromide SCHEMBL6921445 | 0.84 | PLAU (0.61) | PLAUMEN1MAPTKMT2AGAA | |
| SCHEMBL6924845 | 0.82 | KMT2A (0.55) | PLAUMEN1MAPTKMT2AMAPK1 | |
| Bromide SCHEMBL6925948 | 0.82 | PLAU (0.60) | PLAUMEN1MAPTKMT2AGAA | |
| SCHEMBL6925813 | 0.80 | CYP1A1 (0.64) | PLAUMEN1MAPTKMT2AGAA | |
| Bromide SCHEMBL6925534 | 0.78 | PLAU (0.56) | PLAUMEN1MAPTKMT2AALDH1A1 | |
| Bromide SCHEMBL6926455 | 0.78 | PLAU (0.56) | PLAUMEN1MAPTKMT2AMAPK1 | |
| Bromide SCHEMBL6925168 | 0.78 | PLAU (0.56) | PLAUMEN1MAPTKMT2AMAPK1 | |
| Bromide SCHEMBL6926679 | 0.78 | PLAU (0.58) | PLAUMEN1MAPTKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150979-A1 | HETEROARYL AMIDINES, METHYLAMIDINES AND GUANIDINES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000047578-A1 | HETEROARYL AMIDINES, METHYLAMIDINES AND GUANIDINES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | disclosed |